5-Amino-1MQ

5-Amino-1MQ (5-amino-1-methylquinolinium) is not a peptide but is frequently marketed alongside peptides. In the reviewed sources it remains experimental, with no approved human indication and no human clinical efficacy program that could be verified from primary sources.

The molecular target is nicotinamide N-methyltransferase (NNMT). Preclinical chemistry work describes 5-Amino-1MQ as a membrane-permeable NNMT inhibitor with an approximate IC50 near 1 μM. Mechanistically, NNMT inhibition reduces production of 1-methylnicotinamide and theoretically shifts metabolism toward more preserved NAD+ salvage, which is the proposed rationale for the metabolic and adipose-tissue effects seen in rodents.