Chonluten T-34

Immune Modulation

aka T-34 · Glu-Asp-Gly · glutamyl-aspartyl-glycine

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Formula

MW (Da)

Half-life

~few minutes

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Overview

Chonluten (T-34) is a Khavinson tripeptide bioregulator with the sequence Glu-Asp-Gly, originally derived from bronchial epithelial cell studies. The retrieved evidence is narrow and almost entirely in vitro, focused on monocyte/macrophage inflammatory signaling.

Mechanism

The clearest mechanistic signal in the accessible literature comes from a 2022 THP-1 monocyte/macrophage study. In that model, Chonluten inhibited TNF production in monocytes exposed to LPS, reduced TNF and IL-6 expression in differentiated macrophage-like THP-1 cells, increased phosphorylation in mitogen-activated kinase pathways, and reduced monocyte adhesion to activated endothelial cells. The profile is consistent with a modest anti-inflammatory, tolerance-inducing phenotype in vitro, but no validated receptor has been identified and no in vivo pharmacokinetic data are available.

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Reported benefits

Anti-inflammatory signaling in monocyte/macrophage cell models

Inhibited LPS-induced TNF in monocytes, reduced TNF and IL-6 in macrophage-like THP-1 cells, and reduced monocyte adhesion to activated endothelial cells in a 2022 in vitro study.

[chonluten-thp1-2022]

preclinical

Reported side effects

No controlled human safety dataset
anecdotal
The accessible literature is mechanistic and in vitro. Incidence and severity of adverse effects in humans are unspecified.

Dosing notes

Human dose, route, frequency, and safety margins are unspecified in the accessible primary sources. Reported experimental work used laboratory cell exposure, not standardized human administration.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

Peer-reviewed stability data were not retrieved. One commercial research listing reports 2–8 °C storage with ≤ -20 °C for long-term storage, protected from light. Treat this as supplier-specific guidance, not a clinical-quality stability package.

Vendors carrying Chonluten T-34

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Discussion

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References

[chonluten-pubchem]
Glutamyl-aspartyl-glycine (PubChem entry)
PubChem (NIH) · PubChem
Source
[chonluten-thp1-2022]
Peptides regulating proliferative activity and inflammatory pathways in the monocyte/macrophage THP-1 cell line
Authors per ResearchGate entry · 2022 · ResearchGate
Source
[chonluten-maylips]
Chonluten research peptide product listing
Maylips · Vendor product page
Source

Reported benefits

Anti-inflammatory signaling in monocyte/macrophage cell models

No controlled human safety dataset

Discussion