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AminoCatalog

Compounds discussed on this site are research chemicals, not for human consumption. The information here is editorial and has not been evaluated by the FDA.

TB-500 — research peptide reference · AminoCatalog

Peptides Healing & RepairTB-500

TB-500

Healing & Repair

aka Thymosin beta-4 fragment · TB500 · LKKTETQ fragment

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Formula

MW (Da)

Half-life

~few minutes (LKKTETQ fragment; full Tβ4 is ~hours)

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Overview
Vendors
Discussion
References1

Overview

TB-500 — as flagged by the FDA — refers specifically to the thymosin beta-4 fragment LKKTETQ, not full-length thymosin beta-4. The two are frequently conflated in marketing material, but the FDA states it lacks human exposure data for fragment-containing drug products. No approved human medicine exists.

Mechanism

The repair claims for TB-500 are largely extrapolated from full thymosin beta-4 biology, which includes G-actin binding, cell migration, angiogenesis, anti-inflammatory effects, and accelerated wound healing in animal and tissue-repair models. Fragment-specific human efficacy evidence is sparse. Public regulatory records do not treat the fragment as a marketed approved medicine, and FDA explicitly states it lacks important information about whether the fragment would cause harm if administered to humans.

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Reported benefits

In plain terms

TB-500 is the fragment LKKTETQ — NOT full thymosin beta-4, even though they're often conflated online. The wound-healing benefits attributed to TB-500 are mostly extrapolated from full thymosin beta-4 studies, not direct evidence on the fragment itself.

Wound-healing signals from FULL Tβ4 (not the fragment)

Full-length thymosin beta-4 has shown wound-healing and regenerative signals in animal models and early clinical work, but TB-500 fragment-specific human efficacy evidence is sparse.

[tb500-fda-bulk-substances]

preclinical

Reported side effects

In plain terms

The FDA explicitly states it lacks human exposure data for TB-500 fragment products. Don't assume full thymosin beta-4 safety data applies to the fragment.

FDA: no human exposure data for fragment products
anecdotal
The FDA states it has not identified human exposure data for drug products containing thymosin beta-4 fragment, and lacks important information about whether the fragment would cause harm if administered to humans.
Do not transfer full-Tβ4 safety to the fragment
anecdotal
Full-length thymosin beta-4 has been described as safe and well tolerated in early wound-healing studies — this should NOT be assumed to apply to TB-500 fragment products.

Dosing notes

No approved or standardized human dosing for TB-500 fragment. Published thymosin beta-4 studies used investigational topical wound regimens — not interchangeable with off-label injected TB-500.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

No approved, standardized human TB-500 drug product is identified in the FDA material reviewed, so no single authoritative label storage instruction can be quoted. Storage is formulation-specific and should follow exact investigational or supplier documentation.

Vendors carrying TB-500

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Discussion

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References

[tb500-fda-bulk-substances]
FDA: certain bulk drug substances for use in compounding may present significant safety risks
U.S. FDA · FDA
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Editorial info

Last updated: last week
Reviewer: Editorial team

Spotted something wrong? Propose a fix — admin reviewers will see your rationale and sources.

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Research use only. The compounds described on AminoCatalog are research chemicals for laboratory use. Nothing on this site is medical advice. Consult a qualified professional for any health decision.

Reported benefits

Wound-healing signals from FULL Tβ4 (not the fragment)

FDA: no human exposure data for fragment products

Do not transfer full-Tβ4 safety to the fragment

Discussion