Kisspeptin-10

Sexual Health

aka Kp-10 · metastin 45-54 · KISS1-derived decapeptide

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Formula

MW (Da)

Half-life

~3–4 min (IV)

Saves

Overview

Kisspeptin-10 is a short active fragment of kisspeptin and functions as a physiologic upstream trigger of GnRH secretion. Its human evidence is compelling at the level of acute endocrine activation, but far less developed for standardized long-term clinical use.

Mechanism

Kisspeptins act through KISS1R / GPR54, a Gq/11-coupled GPCR. In GnRH neurons, kisspeptin signaling activates PLC-linked pathways and depolarizes the neuron through TRPC-like cation channels combined with partial inhibition of inwardly rectifying K+ (Kir) currents. The consequence is enhanced GnRH pulse generation, followed downstream by increased pituitary LH and FSH and then gonadal steroidogenesis.

Reported benefits

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LH and testosterone stimulation in men

Human work shows kisspeptin-10 is a potent stimulator of LH in men and increases LH pulse frequency and testosterone with continuous exposure.

[kisspeptin-reproductive]

clinical

Reactivation of HPO axis in hyperprolactinemic amenorrhea

In hyperprolactinemic women with chronic amenorrhea, kisspeptin-10 reactivated the hypothalamic-pituitary-ovarian axis, one of the more clinically meaningful human observations for this peptide.

[kisspeptin-reproductive]

clinical

Gonadotropin release with phase-dependent response

Kisspeptin-10 stimulates gonadotropin release in healthy men and in women during the preovulatory phase, with weaker responses in other cycle phases.

[kisspeptin-reproductive]

clinical

Reported side effects

Human adverse-event tables limited
anecdotal
Accessible abstracts of small human endocrine studies did not provide robust adverse-event incidence tables. Serious recurrent safety concerns are not obvious, but human safety remains underdescribed, especially for repeated or chronic dosing.
Favorable nonclinical repeat-dose dog safety
preclinical
A nonclinical repeat-dose dog study reported a favorable safety profile, supportive but not substitutive for human safety data.

Dosing notes

Human experiments used intravenous bolus and infusion paradigms, but the freely accessible abstracts did not consistently disclose a single standardized dose range. No standard clinical dose exists in the retrieved material; published dosing varies by study design, sex, cycle phase, and endpoint.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

No reliable compound-specific storage recommendation was retrieved from primary or manufacturer sources in the reviewed material.

Vendors carrying Kisspeptin-10

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Discussion

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References

[kisspeptin-signaling]
KISS1R / GPR54 signaling in GnRH neurons
Castano and Zhang (review) · PubMed (review)
Source
[kisspeptin-reproductive]
Kisspeptin-10 reproductive hormone effects in humans
George JT, Jayasena CN, Millar RP et al. · PubMed
Source
[kisspeptin-dog-safety]
Nonclinical repeat-dose safety of kisspeptin in dogs
Authors per PubMed entry · PubMed
Source

LH and testosterone stimulation in men

Reactivation of HPO axis in hyperprolactinemic amenorrhea

Gonadotropin release with phase-dependent response

Human adverse-event tables limited

Favorable nonclinical repeat-dose dog safety

Discussion