Nonapeptide-1

Skin & Hair

aka Melanostatine-5 · MC1R antagonist peptide · Skin-brightening nonapeptide

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Formula

MW (Da)

Half-life

topical (negligible systemic absorption)

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Overview

Nonapeptide-1 is a synthetic depigmenting peptide used primarily in cosmetics and skin-brightening research. It is framed as a melanogenesis-modulating peptide rather than a repair peptide or nootropic, and works upstream by antagonizing the α-MSH / MC1R axis.

Mechanism

The central mechanism is antagonism of the α-MSH / MC1R axis, reducing intracellular cAMP signaling and downstream melanogenic activity, including tyrosinase activation. This receptor-level mechanism is attractive because it works "upstream" of some classic pigment inhibitors. Human evidence is still mostly formulation-based: clinical and cosmetic studies have reported improvement in skin-radiance or hyperpigmentation outcomes when nonapeptide-1 is used in combinations, and newer delivery studies have explored melanocyte-targeting formulations to improve depigmenting efficiency.

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Reported benefits

MC1R-antagonist mechanism acts upstream of pigment synthesis

Antagonizing the α-MSH / MC1R axis reduces intracellular cAMP signaling and downstream melanogenic activity, including tyrosinase activation — an "upstream" approach to pigment control.

[nonapep1-pmc-mc1r]

preclinical

Combination-formulation clinical evidence

Clinical and cosmetic studies have reported improvement in skin-radiance or hyperpigmentation outcomes when nonapeptide-1 is used in combinations. Isolated monotherapy data are scarcer.

[nonapep1-medchem]

clinical

Reported side effects

Direct isolated safety data are limited
anecdotal
Direct isolated safety data are more limited than for older ingredients like hydroquinone or niacinamide; the practical human evidence base still comes mostly from combination cosmetics.

Dosing notes

There is no standardized systemic human dose. Nonapeptide-1 is used topically in cosmetic formulations; concentrations vary by product.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

No universal product-specific storage standard was identified. Finished cosmetic formulations should follow label instructions. For raw peptide material: dry, light-protected cold storage, usually around -20°C for lyophilized material.

Vendors carrying Nonapeptide-1

No approved vendors are listing this peptide yet. Check back later or browse the full vendor directory.

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References

[nonapep1-pmc-mc1r]
MC1R-antagonist depigmenting peptides — review
Review authors per PMC entry · PubMed Central
Source
[nonapep1-medchem]
Nonapeptide-1 ingredient profile (MedChemExpress)
MedChemExpress · MedChemExpress
Source