Peptides studied for dermatologic and follicular applications.
15peptides in this category
Skin & Hair
Biopeptide EL is best documented as palmitoyl hexapeptide-12, the palmitoylated elastin fragment Pal-VGVAPG, used as a topical "matrikine" ingredient. It is a distinct molecule from Tripeptide-1 / GHK.
Skin & Hair
Decapeptide-12 is a synthetic 10-amino-acid skin-brightening peptide (commercialized as Lumixyl) that acts as a competitive tyrosinase inhibitor with low melanocyte cytotoxicity in reported assays. Small uncontrolled or split-face clinical studies in melasma and photodamage show modest brightening with a favorable irritation profile relative to hydroquinone.
Skin & Hair
In this report, Matrixyl refers to palmitoyl pentapeptide-4 — the original Matrixyl active. It is a synthetic signal peptide (matrikine) developed for anti-wrinkle cosmetics. Matrixyl 3000 is a different commercial complex built around palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7, which this catalog covers separately under Pal-GHK.
Skin & Hair
Melanotan 1 is best understood clinically as afamelanotide — the active ingredient in SCENESSE, an FDA-approved implant for adults with erythropoietic protoporphyria (EPP). It is not approved as a cosmetic tanning aid.
Skin & Hair
Melanotan II is a synthetic cyclic analogue of α-melanocyte-stimulating hormone. It has never obtained mainstream regulatory approval and appears in official warnings as an unlicensed or unapproved product. Dosing, purity, sterility, and composition of gray-market products are usually not standardized.
Skin & Hair
Nonapeptide-1 is a synthetic depigmenting peptide used primarily in cosmetics and skin-brightening research. It is framed as a melanogenesis-modulating peptide rather than a repair peptide or nootropic, and works upstream by antagonizing the α-MSH / MC1R axis.
Skin & Hair
Pal-AHK is the palmitoylated form of the tripeptide Ala-His-Lys. Direct peer-reviewed literature on the palmitoylated version is very sparse, so most biological rationale comes from broader cosmetic-peptide design principles and from work on the parent AHK or AHK-Cu systems.
Skin & Hair
Pal-GHK is palmitoyl tripeptide-1 — historically also called palmitoyl oligopeptide. It is a GHK-based signal peptide used in cosmetics and is one of the peptide components associated with Matrixyl 3000-style formulations.
Skin & Hair
Pentapeptide-18 (trade name Leuphasyl) is a cosmetic anti-wrinkle peptide with the sequence Tyr-D-Ala-Gly-Phe-Leu, marketed as an enkephalin-mimetic. The original Lipotec dossier used the older proposed INCI name "Pentapeptide-3", a nomenclature inconsistency worth flagging — the molecule is the same.
Skin & Hair
PTD-DBM is a synthetic, cell-penetrating competitor peptide engineered to disrupt the CXXC5-Dishevelled (Dvl) protein-protein interaction. By displacing CXXC5 — a negative feedback regulator of Wnt — it reactivates Wnt/β-catenin signaling and downstream wound-healing and follicle-regeneration programs. No human clinical data identified.
Skin & Hair
SNAP-8 (acetyl octapeptide-3) is an eight-amino-acid extension of Argireline, marketed as a topical cosmetic anti-wrinkle peptide. It is not an approved therapeutic drug. The proposed mechanism is interference with SNARE-complex assembly at the neuromuscular junction, conceptually mirroring botulinum-toxin biology at a much weaker, topical scale.
Skin & Hair
Syn-AKE is the cosmetic ingredient dipeptide diaminobutyroyl benzylamide diacetate — a waglerin-1 inspired peptide designed to antagonize muscular nicotinic acetylcholine receptors. It is a topical cosmetic active, not an approved drug.
Skin & Hair
Syn-Coll is palmitoyl tripeptide-5, a palmitoylated cosmetic signaling peptide positioned as anti-aging and collagen-supporting. The strongest publicly visible evidence is mechanistic and ex vivo rather than large clinical outcome trials.
Skin & Hair
Tripeptide-29 is a collagen-like Gly-Pro-Hyp tripeptide used in cosmetic anti-wrinkle and firmness products. The direct mechanistic evidence base is thin — claims rest on the collagen-mimetic motif and related collagen-tripeptide biology rather than human studies of the molecule itself.
Skin & Hair
Vialox is generally described as pentapeptide-3, a temple-viper inspired topical anti-wrinkle cosmetic active. It is a competitive antagonist at postsynaptic acetylcholine receptors at the cosmetic-level dose.