PE-22-28

Mood & Stress

aka Spadin analog · PE 22-28 · TREK-1 inhibitor peptide

Compare

Formula

MW (Da)

Half-life

~hours (preclinical)

Saves

Overview

PE-22-28 is a shortened analog derived from the spadin program, developed around inhibition of the TREK-1 potassium channel — a target implicated in depression biology. The retrievable indexed literature is preclinical rather than clinical.

Mechanism

The core mechanism is TREK-1 inhibition. Published spadin-analog work reported that PE-22-28 and related analogs showed improved TREK-1 inhibitory potency and antidepressant-like effects in behavioral models, with interest in rapid onset and neurogenic mechanisms. This makes PE-22-28 scientifically interesting in mood-disorder research, especially as a non-monoaminergic approach.

Reported benefits

0

Vendors

—

no vendors yet

Lowest price

—

Improved TREK-1 inhibitory potency vs spadin

Published spadin-analog work reported that PE-22-28 and related analogs showed improved TREK-1 inhibitory potency and antidepressant-like effects in behavioral models.

[pe2228-pmc-spadin]

preclinical

Rapid-onset antidepressant signal in behavioral models

PE-22-28 attracted interest because of rapid onset and neurogenic mechanisms — a non-monoaminergic angle on depression biology.

[pe2228-pubmed-trek]

preclinical

Reported side effects

No human safety characterization
anecdotal
There is no established human dosing standard for PE-22-28 and no approved product label. Earlier TREK-1-blocker molecules in this space were hindered by nonspecificity and safety issues, which is one reason the spadin analog program was developed.

Dosing notes

There is no established human dosing standard for PE-22-28 and no approved product label. Preclinical research uses injection routes appropriate to the animal model under study.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

No product-specific validated storage standard was identified. Standard laboratory peptide handling applies: dry and frozen storage, light and moisture protection, minimal freeze-thaw after reconstitution.

Vendors carrying PE-22-28

No approved vendors are listing this peptide yet. Check back later or browse the full vendor directory.

Discussion

Ask, answer, and vote on questions about PE-22-28.

No questions yet. Be the first to ask.

References

[pe2228-pubmed-trek]
PE-22-28 and TREK-1 inhibition in antidepressant research
Authors per PubMed entry · PubMed
Source
[pe2228-pmc-spadin]
Spadin analogs including PE-22-28 — improved TREK-1 potency
Authors per PMC entry · PubMed Central
Source
[pe2228-pubmed-safety]
Earlier TREK-1 blockers — nonspecificity and safety concerns
Authors per PubMed entry · PubMed
Source

Improved TREK-1 inhibitory potency vs spadin

Rapid-onset antidepressant signal in behavioral models

No human safety characterization

Discussion