Peptides studied for stress response and mood regulation.
4peptides in this category
Mood & Stress
Delta sleep-inducing peptide (DSIP) is a nonapeptide first described in the 1970s with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. Reviews still describe it as "a still unresolved riddle": the endogenous precursor is unknown, the receptor system is undefined, and the physiological role is incompletely established despite decades of work.
Mood & Stress
N-Acetyl Selank is an acetylated Selank analog. PubChem catalogs the molecule, but direct human clinical literature for the modified form is notably sparse. The functional claims around it are largely extrapolated from the parent peptide Selank — a tuftsin-derived heptapeptide studied in Russian anxiety-related literature.
Mood & Stress
PE-22-28 is a shortened analog derived from the spadin program, developed around inhibition of the TREK-1 potassium channel — a target implicated in depression biology. The retrievable indexed literature is preclinical rather than clinical.
Mood & Stress
Selank is a synthetic tuftsin analog (Thr-Lys-Pro-Arg-Pro-Gly-Pro) marketed in Russia as a 0.15% intranasal drop. It functions as an anxiolytic neuropeptide without a single universally accepted receptor mechanism. It is not FDA or EMA approved.