Pinealon

Cognitive & Nootropic

aka EDR · EDR tripeptide · Glu-Asp-Arg

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Formula

MW (Da)

Half-life

~few minutes

Saves

Overview

Pinealon is the EDR tripeptide (Glu-Asp-Arg), a Khavinson-school neuroregulatory bioregulator. Russian references list it as a dietary supplement rather than a prescription medicinal product, and it has no FDA or EMA drug approval.

Mechanism

Pinealon's mechanism remains noncanonical and incompletely validated. Rather than acting through a single well-characterized receptor, the literature describes interaction with DNA and modulation of gene expression and protein synthesis. A primary cell study reported suppression of ROS overproduction, delayed ERK1/2 activation, and cell-cycle effects accompanying improved cell viability. Animal work reports neuroprotection in prenatal hyperhomocysteinemia models with improved offspring cognitive function. The signals are biologically plausible but do not constitute a validated target-engagement framework by mainstream drug-development standards.

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Reported benefits

Cell-level neuroprotective signals

In vitro work shows improved cell viability with ROS suppression, delayed ERK1/2 activation, and cell-cycle modulation in stressed neuronal cell models.

[pinealon-pubmed-21978084]

preclinical

Sparse Russian observational human data

Pinealon at 100 mcg twice daily for 2 weeks was reported to improve "biological age" parameters and adaptive reactions in railway workers. A 2015 gerontology report recommended it as a geroprotector, and a 2020 EDR review references 72 patients with traumatic-brain-injury sequelae — methodological detail is limited in English indexing.

[pinealon-edr-review-2020]

clinical

Reported side effects

No modern adjudicated adverse-event dataset
anecdotal
No modern, well-documented human safety trial with adjudicated adverse-event rates was identified. Absence of evidence is not evidence of harm, but quantitative safety claims cannot be made from the accessible literature.

Dosing notes

One accessible Russian human report used 100 mcg orally twice daily for 2 weeks. No standardized contemporary regimen with validated safety margins exists in English indexed sources.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

The Russian supplement monograph specifies dry, light-protected storage at 2–25 °C with a 5-year shelf life for capsule products. No authoritative reconstitution or shelf-life standard is available for injectable research-only formulations sold outside regulated drug channels.

Vendors carrying Pinealon

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References

[pinealon-pubchem-edr]
Glu-Asp-Arg (PubChem entry for EDR tripeptide)
PubChem (NIH) · PubChem
Source
[pinealon-rlsnet]
Pinealon supplement monograph (RLS Russian drug registry)
RLS (Russian drug registry) · Russian RLS supplement monograph
Source
[pinealon-edr-review-2020]
Khavinson et al. 2020 EDR / Pinealon review
Khavinson VK et al. · 2020 · Molecules (PMC review)
Source
[pinealon-nazimko]
Pinealon in railway workers — biological age and adaptive reactions
Nazimko et al. · PubMed
Source
[pinealon-pubmed-21978084]
Pinealon mechanistic primary cell study
Khavinson VK et al. · 2011 · PubMed
Source