Peptides studied for senescence, mitochondrial function, and aging biomarkers.
4peptides in this category
Longevity
Epithalon (Epitalon, AEDG) is a synthetic tetrapeptide developed as a defined analog related to epithalamin, a pineal polypeptide preparation. The compound is best known in the Khavinson gerontology literature; modern independent human trial evidence is sparse, and the strongest data remain cellular.
Longevity
FOXO4-DRI is a designed D-retro-inverso peptide built from the FOXO4 interaction surface and engineered to disrupt the FOXO4–p53 axis specifically in senescent cells. It is a research-stage senolytic with no human clinical trials in the retrieved literature.
Longevity
Humanin is a small endogenous mitochondrial-derived peptide with a remarkable preclinical portfolio in apoptosis resistance, neuroprotection, metabolic regulation, and ischemia-reperfusion injury. Translated human clinical evidence remains very limited.
Longevity
NAD+ is a coenzyme — not a peptide. It is central to redox metabolism and serves as a substrate for enzymes tied to DNA repair, stress responses, and aging biology, including PARPs and sirtuins. Included here for completeness from the source dossier. The "longevity" reputation is well ahead of the controlled clinical evidence.