Tripeptide-29

Skin & Hair

aka Gly-Pro-Hyp · Collagen-tripeptide GPH · Tripeptide-29 cosmetic active

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Formula

MW (Da)

Half-life

topical (negligible systemic absorption)

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Overview

Tripeptide-29 is a collagen-like Gly-Pro-Hyp tripeptide used in cosmetic anti-wrinkle and firmness products. The direct mechanistic evidence base is thin — claims rest on the collagen-mimetic motif and related collagen-tripeptide biology rather than human studies of the molecule itself.

Mechanism

Tripeptide-29's proposed mechanism is collagen signaling based on its collagen-mimetic Gly-Pro-Hyp motif and related collagen-tripeptide biology. Direct human mechanistic confirmation for topical Tripeptide-29 itself is limited. A Korean study discussed anti-wrinkle effects for a palmitoylated derivative, and supplier technical literature describes Tripeptide-29 as an anti-wrinkle and tightening active.

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Reported benefits

Collagen-mimetic motif-based mechanism (proposed)

Activity is proposed via collagen signaling, based on the Gly-Pro-Hyp collagen-mimetic motif. Direct human mechanistic confirmation for topical Tripeptide-29 itself is limited.

[tripeptide29-koreascience]

preclinical

Supplier descriptions of anti-wrinkle / tightening activity

Supplier technical literature describes Tripeptide-29 as an anti-wrinkle and tightening cosmetic active. Confidence is materially weaker than for approved endocrine peptides.

[tripeptide29-specialchem]

anecdotal

Reported side effects

No standardized adverse-effect profile in public sources
anecdotal
Publicly accessible sources reviewed do not provide a standardized Tripeptide-29 adverse-effect profile; side-effect certainty remains low.

Dosing notes

No approved drug dosing. Topical use levels are formulation-specific and were not standardized in the accessible public sources.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

No clear public monograph with standardized storage instructions for Tripeptide-29 itself was identified. Storage should follow the exact supplier and formulation documentation.

Vendors carrying Tripeptide-29

No approved vendors are listing this peptide yet. Check back later or browse the full vendor directory.

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References

[tripeptide29-koreascience]
Korean study on a palmitoylated tripeptide-29 derivative for anti-wrinkle effects
Korean Society authors · KoreaScience
Source
[tripeptide29-specialchem]
Active Peptide Tripeptide-29 Collagen Solution product page
SpecialChem · SpecialChem product listing
Source