Syn-Coll

Skin & Hair

aka Palmitoyl Tripeptide-5 · Palmitoyl Oligopeptide cosmetic active

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Formula

MW (Da)

Half-life

topical (negligible systemic absorption)

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Overview

Syn-Coll is palmitoyl tripeptide-5, a palmitoylated cosmetic signaling peptide positioned as anti-aging and collagen-supporting. The strongest publicly visible evidence is mechanistic and ex vivo rather than large clinical outcome trials.

Mechanism

Ingredient and review material describe Syn-Coll as a signaling peptide that activates TGF-β-related pathways and stimulates collagen synthesis. Ex vivo human-skin work associated palmitoyl tripeptide-5-containing systems with improved fibroblast morphology, inhibition of elastin glycation, and increased procollagen markers. The strongest publicly visible support is mechanistic and ex vivo, not large-scale clinical outcome data.

Reported benefits

0

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Ex vivo collagen and elastin-glycation effects

Ex vivo skin studies report improved fibroblast morphology, inhibition of elastin glycation, and increased procollagen markers with palmitoyl tripeptide-5-containing systems.

[syncoll-makingcosmetics]

preclinical

Proposed TGF-β-related signaling

Public ingredient and review material describes the peptide as a signaling peptide that activates TGF-β-related pathways and stimulates collagen synthesis. Direct human clinical data are limited.

[syncoll-experchem-tds]

preclinical

Reported side effects

No standardized human adverse-effect dataset
anecdotal
Peptide-specific human adverse-effect tables are not clearly standardized in publicly accessible sources. Safety certainty is lower than for approved medicines.

Dosing notes

No approved medical dose. Topical use levels are supplier- and formulation-specific; the accessible public sources did not establish a single universal topical use level.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

One cosmetic product information sheet lists 2–8 °C storage in a dark, clean environment; some research-grade supplier sheets list colder storage for raw material. Avoid heat and direct sunlight for formulated material.

Vendors carrying Syn-Coll

No approved vendors are listing this peptide yet. Check back later or browse the full vendor directory.

Discussion

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References

[syncoll-makingcosmetics]
Syn-Coll (palmitoyl tripeptide-5) cosmetic active product page
MakingCosmetics · MakingCosmetics product page
Source
[syncoll-experchem-tds]
Palmitoyl tripeptide-5 product information (ExperChem)
ExperChem · ExperChem technical data sheet
Source

Ex vivo collagen and elastin-glycation effects

Proposed TGF-β-related signaling

No standardized human adverse-effect dataset

Discussion