Matrixyl

Skin & Hair

aka Palmitoyl pentapeptide-4 · Pal-KTTKS · Palmitoyl pentapeptide-3 (older INCI)

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Formula

MW (Da)

Half-life

topical (negligible systemic absorption)

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Overview

In this report, Matrixyl refers to palmitoyl pentapeptide-4 — the original Matrixyl active. It is a synthetic signal peptide (matrikine) developed for anti-wrinkle cosmetics. Matrixyl 3000 is a different commercial complex built around palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7, which this catalog covers separately under Pal-GHK.

Mechanism

Palmitoyl pentapeptide-4 is linked to extracellular-matrix signaling. Reviews describe it as related to fragments of procollagen I and report stimulation of ECM components such as collagen, elastin, fibronectin, and glycosaminoglycans. In the classic clinical study, topical palmitoyl pentapeptide improved photoaged facial skin and was well tolerated against placebo control.

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Reported benefits

Improved photoaged facial skin in placebo-controlled trial

In the classic clinical study, topical palmitoyl pentapeptide improved photoaged facial skin and was well tolerated against placebo control.

[matrixyl-mdpi-cosmetics]

clinical

Stimulates collagen, elastin, fibronectin, GAGs in vitro

Reviews report palmitoyl pentapeptide-4 stimulates ECM components including collagen, elastin, fibronectin, and glycosaminoglycans — the mechanistic basis for its anti-wrinkle claims.

[matrixyl-mdpi-cosmetics]

preclinical

Well tolerated at 3 ppm in 12-week clinical study

In a 12-week clinical study, a moisturizer with 3 ppm palmitoyl pentapeptide-4 was well tolerated in 93 women.

[matrixyl-cir]

clinical

Reported side effects

CIR (2024): safe at present cosmetic use and concentration
clinical
The 2024 final Cosmetic Ingredient Review report concluded that palmitoyl pentapeptide-4 is safe in present practices of cosmetic use and concentration.
Use concentrations are very low
clinical
Reported use concentrations are low — highest leave-on face/neck at 0.0012%, with overall use up to 0.0035% in hair conditioners.

Dosing notes

Topical only. CIR-reported concentrations: up to 0.0012% leave-on face/neck and up to 0.0035% in hair conditioners. The 12-week clinical trial used a 3 ppm moisturizer. No systemic or injectable dosing exists.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

For finished skincare, follow the product label. For raw peptide material, generic peptide handling: frozen, dry, light-protected storage, often at -20°C or below.

Vendors carrying Matrixyl

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References

[matrixyl-pubchem]
Matrixyl / palmitoyl pentapeptide-4 (PubChem)
PubChem · PubChem
Source
[matrixyl-mdpi-cosmetics]
Topical palmitoyl pentapeptide for photoaged skin (MDPI Cosmetics)
Authors per MDPI entry · MDPI Cosmetics
Source
[matrixyl-cir]
CIR final report on pentapeptides (2024)
Cosmetic Ingredient Review · CIR
Source