Pal-GHK

Skin & Hair

aka Palmitoyl tripeptide-1 · Palmitoyl oligopeptide · Pal-Gly-His-Lys

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Formula

MW (Da)

Half-life

topical (negligible systemic absorption)

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Overview

Pal-GHK is palmitoyl tripeptide-1 — historically also called palmitoyl oligopeptide. It is a GHK-based signal peptide used in cosmetics and is one of the peptide components associated with Matrixyl 3000-style formulations.

Mechanism

Pal-GHK is treated as a signal peptide or matrikine-mimetic that can support extracellular-matrix renewal. Reviews describe it as a collagen-signaling peptide; the palmitoyl group improves cutaneous affinity, supporting topical use for wrinkle reduction and dermal-repair signaling. The main limitation is that clinical data are usually combination-formulation data rather than isolated monotherapy studies — eye-cream and facial-cream trials containing palmitoyl peptide combinations have reported improvements in wrinkles, firmness, hydration, elasticity, and collagen-density-related measures.

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Reported benefits

Combination-formulation cosmetic clinical signals

Eye-cream and facial-cream trials containing palmitoyl peptide combinations have reported improvements in wrinkles, firmness, hydration, elasticity, and collagen-density-related measures.

[palghk-pmc-clinical]

clinical

Matrikine-mimetic collagen signaling

Reviews describe Pal-GHK as a collagen-signaling peptide; the palmitoyl group improves cutaneous affinity to support topical wrinkle and dermal-repair endpoints.

[palghk-cir]

preclinical

Reported side effects

CIR: safe in present cosmetic use and concentration
clinical
CIR concluded that palmitoyl tripeptide-1 and related ingredients in that family are safe in present cosmetic use and concentration. CIR-described concentrations ranged from 0.0000001% to 0.002%.
Typical industry use ~1–30 ppm
clinical
Industry submissions to CIR indicated typical peptide use around 1 ppm to 30 ppm, often below 10 ppm — a reasonable topical "dosing note."

Dosing notes

Topical only. CIR-reported concentrations: 0.0000001% to 0.002%, with industry typical use around 1 ppm to 30 ppm (often below 10 ppm). No recognized systemic or injectable human dosing standard.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

For finished skincare, follow the manufacturer label. For raw peptide: frozen dry storage, light protection, and careful handling after reconstitution.

Vendors carrying Pal-GHK

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References

[palghk-cir]
CIR report on palmitoyl tripeptide-1 and related tripeptides (2014)
Cosmetic Ingredient Review · CIR
Source
[palghk-pmc-clinical]
Palmitoyl-peptide combination cosmetic clinical trials
Authors per PMC entry · PubMed Central
Source