SNAP-8

Skin & Hair

aka Acetyl Octapeptide-3 · Acetyl Octapeptide-1 · Argireline extension

Compare

Formula

MW (Da)

Half-life

topical (negligible systemic absorption)

Saves

Overview

SNAP-8 (acetyl octapeptide-3) is an eight-amino-acid extension of Argireline, marketed as a topical cosmetic anti-wrinkle peptide. It is not an approved therapeutic drug. The proposed mechanism is interference with SNARE-complex assembly at the neuromuscular junction, conceptually mirroring botulinum-toxin biology at a much weaker, topical scale.

Mechanism

Cosmetic reviews position SNAP-8 as a neuromodulatory topical peptide that interferes with SNARE-complex assembly involved in neurotransmitter release at the neuromuscular junction. The effect is conceptual rather than equivalent to botulinum-toxin pharmacology. Dissolving microneedle delivery has been explored to improve cutaneous penetration and stability. Independent mechanistic confirmation in human skin remains limited.

0

Vendors

—

no vendors yet

Lowest price

—

Reported benefits

Up to ~38% wrinkle-depth reduction in cosmetic studies

Reviews report up to about a 38% reduction in wrinkle depth after 28 days of topical use, especially in high-expression zones such as the periorbital region.

[snap8-mdpi-cosmetics-review]

clinical

Microneedle delivery research

Dissolving microneedle systems have been explored to improve cutaneous penetration and stability of SNAP-8.

[snap8-mdpi-cosmetics-review]

preclinical

Reported side effects

Generally good topical tolerability per cosmetic reviews
anecdotal
Cosmetic reviews describe good tolerability in topical use; large independent safety datasets are limited compared with regulated drug products.

Dosing notes

No approved medical dosing. Use is topical cosmetic only. The accessible public sources did not establish a single universal formulation percentage.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

Supplier guidance varies. One source lists long-term storage at 2–8 °C; another lists -20 °C. Finished-product or supplier-specific instructions should govern storage for a given material.

Vendors carrying SNAP-8

No approved vendors are listing this peptide yet. Check back later or browse the full vendor directory.

Discussion

Ask, answer, and vote on questions about SNAP-8.

No questions yet. Be the first to ask.

References

[snap8-mdpi-cosmetics-review]
Topical peptide actives for skin: a comprehensive cosmetics review (2024)
Review authors per MDPI Cosmetics · 2024 · MDPI Cosmetics (review)
Source