Syn-AKE

Skin & Hair

aka Dipeptide Diaminobutyroyl Benzylamide Diacetate · DSM Syn-AKE · waglerin-1 inspired peptide

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Formula

MW (Da)

Half-life

topical (negligible systemic absorption)

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Overview

Syn-AKE is the cosmetic ingredient dipeptide diaminobutyroyl benzylamide diacetate — a waglerin-1 inspired peptide designed to antagonize muscular nicotinic acetylcholine receptors. It is a topical cosmetic active, not an approved drug.

Mechanism

Syn-AKE is designed to antagonize muscular nicotinic acetylcholine receptors at the topical/cosmetic level, helping keep the ion channel closed and reducing sodium influx and downstream muscle contraction linked to expression lines. DSM's public material describes wrinkle-smoothing effects; review literature summarizes up to 52% wrinkle-size reduction in topical studies over four weeks.

Reported benefits

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Reported wrinkle-size reductions up to 52% in topical studies

A recent review summarizes wrinkle-size reductions of up to 52% in topical studies over four weeks. DSM material describes wrinkle-smoothing including reductions in deep wrinkles.

[synake-mdpi-cosmetics-review]

clinical

Reported side effects

Favorable topical safety profile in cosmetic literature
anecdotal
Public cosmetic literature describes a generally favorable topical safety profile. Robust independent adverse-event reporting remains limited.

Dosing notes

DSM formulation guide: 1–4% SYN-AKE in skincare preparations; recommended final formulation pH 3.0–7.5; incorporate preferably below 40 °C.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

DSM's public formulation guide does not publish a storage temperature and refers users to the product data sheet. Treat exact storage as manufacturer-lot specific.

Vendors carrying Syn-AKE

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References

[synake-dsm-guidelines]
SYN-AKE formulation guidelines (2020)
DSM Personal Care · 2020 · DSM formulation guide
Source
[synake-mdpi-cosmetics-review]
Topical peptide actives for skin: a comprehensive cosmetics review (2024)
Review authors per MDPI Cosmetics · 2024 · MDPI Cosmetics (review)
Source

Reported wrinkle-size reductions up to 52% in topical studies

Favorable topical safety profile in cosmetic literature

Discussion