Biopeptide EL

Skin & Hair

aka Lipopeptide · Palmitoyl hexapeptide-12 · Pal-VGVAPG

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Formula

MW (Da)

Half-life

topical (negligible systemic absorption)

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Overview

Biopeptide EL is best documented as palmitoyl hexapeptide-12, the palmitoylated elastin fragment Pal-VGVAPG, used as a topical "matrikine" ingredient. It is a distinct molecule from Tripeptide-1 / GHK.

Mechanism

The underlying hexapeptide VGVAPG is a repeating elastin motif that is chemotactic for fibroblasts and monocytes, which gives a plausible basis for tissue-remodeling or matrikine signaling. Manufacturer product documentation states that palmitoylated VGVAPG stimulates collagen, elastin, fibronectin, and glycosaminoglycan production and may reduce IL-6 in skin cells. The palmitoyl group is used to make the peptide more suitable for topical incorporation. The strongest hard evidence is the classic elastin-peptide chemotaxis work; the downstream cosmetic skin claims are more formulation- and manufacturer-driven.

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Reported benefits

Elastin-motif chemotaxis for fibroblasts and monocytes

The VGVAPG repeating elastin motif is chemotactic for fibroblasts and monocytes, providing a plausible basis for tissue-remodeling and matrikine signaling.

[vgvapg-chemotaxis]

preclinical

Manufacturer cosmetic efficacy claims

Manufacturer in vivo material reports improved skin tone, firmness, slackening, and flaccidity after topical use, with one product sheet citing roughly +20% skin tone, +33% firmness, -17% slackening, and -19.6% flaccidity. These are manufacturer efficacy data, not independent therapeutic clinical-trial outcomes.

[biopeptide-el-overview]

anecdotal

Reported side effects

Low ocular irritation in rabbit testing
preclinical
A cosmetic safety review identifies Biopeptide EL as palmitoyl VGVAPG and reports rabbit ocular testing in which it was considered non-irritating under the facility criteria. Reassuring for topical exposure but not a substitute for systemic safety data.
Systemic human safety absent
anecdotal
Human systemic safety data are absent. The only available safety information is topical and animal-based.

Dosing notes

One product-overview sheet recommends adding Biopeptide EL directly to emulsions at about 45 C or into gels at room temperature, at a 2-5% use level. This is a topical formulation recommendation, not a validated medical dose.

Research use only. Information on this page is editorial reference, not medical or dosing advice. Always consult qualified medical guidance before use.

Storage

An ingredient datasheet for palmitoyl hexapeptide-12 / Biopeptide EL recommends 2 to 8 C, cool, dark, and clean storage, with a 24-month shelf life. Official Croda product pages describe it as a liquid peptide ingredient at room temperature.

Vendors carrying Biopeptide EL

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References

[croda-biopeptide-el]
Biopeptide EL product page
Croda · Croda Beauty product page
Source
[biopeptide-el-overview]
Biopeptide EL product overview and efficacy sheet
Distributor product sheet · Product overview sheet
Source
[cir-palmitoyl-oligopeptides]
CIR safety assessment of palmitoyl oligopeptides
Cosmetic Ingredient Review · Cosmetic Ingredient Review
Source
[vgvapg-chemotaxis]
Chemotactic activity of elastin-derived VGVAPG peptide
Senior RM et al. · 1984 · PubMed
Source
[experchem-pal-hex12]
Palmitoyl hexapeptide-12 product information
ExperChem · ExperChem product information
Source